Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 2nd International Conference on Spine and Spinal Disorders Rome, Italy.

Day 2 :

Keynote Forum

Bin Zhang

Icahn Institute of Genomics and Multi-scale Biology, USA

Keynote: Molecular networks shared by Parkinson’s disease and Alzheimer’s disease

Time : 10:00-10:40

OMICS International Spine 2017 International Conference Keynote Speaker Bin Zhang  photo
Biography:

Bin Zhang is a Professor (pending) of the Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA. His expertise lies in Systems Biology, Machine Learning and Pattern Recognition. He has developed a series of influential gene network inference algorithms which have been extensively used for identification of novel pathways and gene targets, as well as development of drugs for several major human diseases. As a Prolific Researcher, he has published a number of high profile papers in Nature, Science, Cell, Nature Genetics and PNAS. As of January of 2017, his publications have been cited 11,386 times

Abstract:

Parkinson's diseases (PD) and Alzheimer's (AD) have been shown to share extensive clinical and pathological features. For example, most PD patients with dementia have neurofibrillary tangles and senile plaques. At the molecular level, dysregulation of pathways such as immune response and autophagy have been observed in both PD and AD. The latest genetics studies of PD and AD further reveal that polymorphisms in HLA, MAPT and PICALM are associated with both PD and AD. To systematically investigate the commonality in molecular interactions between PD and AD, we performed multiscale embedded gene co-expression network analysis (MEGENA) on a large cohort of gene expression data from over 150 PD brain samples and two large cohorts of RNA-sequencing data from over 800 AD brain samples. Microglia/immune enriched modules in AD and PD are most conserved (P=1.26e-209, 15 fold enrichment). The other conserved gene modules, which are involved in synaptic transmission, transmission of nerve impulse, monovalent inorganic cation transport and cholesterol metabolism, are significantly enriched for the respective differentially expressed gene signatures between disease and control, indicating common molecular mechanisms underlying the two neurodegenerative diseases. We further evaluated the network rewiring of these conserved modules between PD and AD. The converged, disease-associated molecular networks identified here not only reinforce the findings from PD and AD specific studies, but also provide a general framework to study the two diseases simultaneously.
 

Keynote Forum

Walid Ismail Attia

National Neuroscience Institute, Saudi Arabia

Keynote: Complex spine revisions: Dream or nightmare for spine surgeons

Time : 10:40-11:20

OMICS International Spine 2017 International Conference Keynote Speaker Walid Ismail Attia photo
Biography:

Walid Ismail Attia is a Consultant Neurosurgery and Spine Surgery Director at King Fahad Medical City. He completed his Bachelor of Medicine/Bachelor of Surgery at Tanta University, Egypt and Residency in Neurosurgery at Tanta University Hospital, Egypt.
 

Abstract:

Introduction: The type and extent of revision surgeries carried out in the management of complex spine iatrogenic disorders still lacks evidence based medicine proof. It is up to the health care provider’s sound judgment and expertise to do what is needed for the patient. Management challenges include, yet not limited to; dealing with infected or deformed hardware, decompression near vital vascular or neural structures- already distorted by adhesions or radiation effects-, decompression at a blind angle, difficult deformities corrections and difficult trajectories for re-instrumentation. The use of intraoperative CTquality O-arm and neuronavigation are still tested as aiding tools in such operative modalities. Methods: Among our 600+ cases operated with guidance of O-arm and neuronavigation since 2008, we randomly selected four cases of complex spine modalities that were operated upon in our institute by the authors to be included in this retrospective study. Cases include traumatic spinal fractures, complex-degenerative, infective, inflammatory-disorders, benign and malignant neoplasms affecting different parts of the spinal column. All of them had technical challenges. All had undergone a combination of decompression deformity correction, and instrumentation of different modalities and/or bone grafting. In all cases the Medtronic O-arm® and Medtronic StealthStation® were used as intraoperative mapping tools. Results: We managed to safely remove the problematic hardware, deal with the underlying pathology, reapply the new hardware to an acceptable degree, and secure safe neurologic result of all surgeries in the series despite the high technical challenges. Conclusion: The intraoperative use of the O-arm and stealth Station is very useful in different modalities of complex spine surgeries.